Depending on the material being used, different on-chip pump mechanisms can be applied to realize fluid transportation in a closed system scenario. One possible solution is the fluid manipulation via one (or more) integrated elastomeric air reservoir, called bellow, realized by a two-component injection molding process. The bellow volume is modified by an instrument-based actuator and due to the hermetically sealed design of the consumable itself, this compression leads to a fluid manipulation. Bellow relaxation on the other hand enables reversal of flow direction. A different approach is the implementation of a thin-film pump, also mechanically operated by the instrument, into a closed-loop fluidic network. Two layers of film being assembled to the consumable are deflected to form a pump cavity and are operated similar to a peristaltic pump. Both solutions are equally well suited for mass manufacturing processes and facilitate completely sealed and selfcontained cartridge designs as a prerequisite for contamination control.