Partnership Studies

Keep Your Eye on Innovation.
Let us Handle the Integration.

Through strategic partnerships, IDEX Health & Science engineers innovative components that result in optimized optofluidic systems. We don’t just build components; we also create innovative solutions that maximize performance and enable the complete optimization of the entire optofluidic pathway. We manufacture highly trusted products used in life science instruments that perform precise sampling, reagent handling, optical analysis, sample processing, and many other analysis tasks.

Browse through our case studies below to see how partnership is the new innovation:

breakthrough solutions, strategic partnership, proven expertise
reproducibility and reliability icon
enhanced valve capabilities icon
reduce risk of contamination icon
engineered efficiency icon
autofocusing between consumable and instrument icon
optimized liquid reagent storage icon
enhanced sampling icon
long life pumping icon
antibody titer monitoring story icon
dry reagent storage icon
optimized material icon
reagent conditioning icon

 

reproducibility and reliability icon

Reproducibility & Reliability

CUSTOMER REQUIREMENT:
Our partner needed a highly advanced microfluidics interface.

SOLUTION:
We used our expertise in engineered thermoplastics, process control, and manufacturing to create a fluidic manifold that met the demands of ultra-low-volume analysis and allowed the easy interchange of consumable microfluidic chips.

 

 

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Enhance Valve Capabilities

CUSTOMER REQUIREMENT:
Our partner required precise control of multiple reagents.

SOLUTION:
Our rotary shear valves provide complex flow-switching without accidental flow pumping. These features enhance applications that use multiple reagents, where carryover or accidental flow would hinder the analysis.

 

 

reduce risk of contamination icon

Reduce Risk of Critical Biological Contamination

CUSTOMER REQUIREMENT:
Our partner required a pump mechanism for self-contained cartridges.

SOLUTION:
Our engineers developed two different approaches to this problem which are both equally well suited for mass manufacturing and facilitate completely sealed and self-contained cartridge designs. First, is fluid manipulation using a bellow. Bellow volume is modified by an instrument-based actuator and due to the hermetically sealed design of the consumable itself, this compression leads to a fluid manipulation. Second, is the implementation of a thin-film pump, also mechanically operated by the instrument, into a closed-loop fluidic network. Two layers of film being assembled to the consumable are deflected to form a pump cavity and are operated similar to a peristaltic pump.

 

 

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Engineered Efficiency

CUSTOMER REQUIREMENT:
Our partner required a compact, low pressure, low power consumption pump for diagnostics.

SOLUTION:
We created a compact, multi-channel peristaltic pump with three digitally-controlled fluid drives in a single panel-mount package. This innovative design reduces system components and provides streamlined controls for automation.

 

 

autofocusing between consumable and instrument icon

Autofocusing Between Consumable & Instrument

CUSTOMER REQUIREMENT:
Our partner required alignment across applications from tens to hundreds of microns.

SOLUTION:
Our engineers installed a Ronchi Grating directly onto the consumable, allowing active alignment by autofocusing. Since the grating is located in a defined proximity to the detection channel, the instrument can easily detect the position of the disposable and fine-tune for optical read-out.

 

 

optimized liquid reagent storage icon

Optimized Lab-on-a-Chip Liquid Reagent Storage

CUSTOMER REQUIREMENT:
Our partner required protection and preservation of reagent stability during manufacturing, assembly, and long-term storage.

SOLUTION:
Our lab-on-a-chips feature liquid reagents stored in both blister packs and in cavities on the chip. A controlled release of the liquid reagent is achieved with a frangible seal on the channel which connects the blister to the rest of the fluidic network of the cartridge.

 

 

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Enhanced Sampling

CUSTOMER REQUIREMENT:
Our partner asked us to help minimize carryover and fluid loss during sample introduction.

SOLUTION:
Our support team worked closely with the customer to teach valve operation, sample loop overfill, rinsing, and pressure equalization methods. These procedures were used in the instrument after collaborative validation, resulting in a significant increase in system reliability.

 

 

long life pumping icon

Ultra-Long Life Pumping

CUSTOMER REQUIREMENT:
Our partner required high-precision, ultra-long life, positive displacement pump for application in protein analysis.

SOLUTION:
Our engineers designed a screw-driven pump with an energized seal and an ultra-smooth, ultra-hard piston that has unsurpassed life length and industry-leading precision.

 

 

Anitbody Titer Monitoring Story Icon

Real-Time Monitoring of Antibody Titer

CUSTOMER REQUIREMENT:
Our partner needed a simple, cost-effective, and quick method to measure antibody concentration. Their existing procedures were to measure titer retroactively in their QC lab, which required a minimum of 24-hour turnaround time, or for bioproduction staff to measure titer using high-performance liquid chromatography (HPLC) instrument which is time consuming and complex to operate.

SOLUTION:
We partnered with an industry-leading biopharma contract research organization (CRO) to review the difficult techniques typically used for determining titer during cell culture or after harvest and brainstormed a new approach to delivering a cost-effective antibody measurement. During product development, the CRO provided us with industry insights from their large client base and could answer questions based on what they have seen. After extensive testing and competitive research, we created Tridex™, the first protein analyzer on the market built specifically for bioprocess monitoring. Tridex can be used in several steps throughout the development of biologic drugs, demonstrating that innovative solutions are possible through collaborations across the drug development and manufacturing network.

 

 

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Scalable Solution for Dry Reagent Storage

CUSTOMER REQUIREMENT:
Our partner needed storage of dry reagents for complex assays that are reliable, cost effective, and scalable.

SOLUTION:
Reagents are dispensed and dried onto reagent carriers called reagent plugs. These plugs are prepared independently from the cartridge in larger batches, functionalized on a SBS titerplate format and assembled to the cartridge in a final assembly step. The processes for dry reagent preparation can be developed and performed independently of the cartridge manufacturing processes using standard equipment and has been proven to be scalable and compatible with industrial functionalization and assembly processes.

 

 

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Optimized Materials

CUSTOMER REQUIREMENT:
Our partner required rigid, high-tolerance sample probe arrays for biological analysis.

SOLUTION:
We developed composite metal / thermoplastic probe assemblies with the strength and precision of metal and the biological compatibility of a wetted flow path. These engineering innovations ensure reliable probe integrity, every time for every instrument.

 

 

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High-Performance Reagent Conditioning

CUSTOMER REQUIREMENT:
Our partner required help with low-impact solvent degassing.

SOLUTION:
Our dynamic vacuum-level control system provides optimized degassing while protecting solvent composition. The result is extremely high quality degassing with minimal detriment, that greatly enhances run-to-run reliability.