Fluidics

Improve Fluidic Instrument Precision with Degassers

Reduce air bubble and dissolved gas interference in your fluidic system and improve the analysis result quality with IDEX Health & Science degassers.

Dissolved gases in reagent lines can lead to bubble formation, disrupting analysis results and causing errors in fluidic systems. IDEX Health & Science inline degassing modules efficiently remove dissolved gases from a variety of fluids, ensuring optimal fluidic performance for your instrument. The fully swept flow design of our degassers ensures minimal hydrodynamic impact; dissolved gas level can be conveniently controlled through our adjustable vacuum pumps.

Benefits and Features of IDEX Health & Science Degassers:

IDEX Health & Science degassers

Improve analysis result quality

  • Efficient inline dissolved gas and air bubble removal
  • Fully-swept chamber design
  • Adjustable degassing level

Inert materials offer chemical compatibility across a broad range of buffers and reagents

  • Silicone or Teflon AF degassing membranes
  • PVC or PEEK housing

Simple integration

  • Conventional fluidic ports
  • Compact design
  • Self-regulating long life vacuum source
  • High-level command set available for serial communication with vacuum pumps
  • Newest vacuum pumps are compatible with the IDEX Health & Science library for advanced fluidic system control

Why consider degassing for your platform?

Dissolved gasses can cause issues with your instrument precision. Changes in the temperature, pressure, or reagent mixing can cause the gas solubility of your system fluid to change. When this happens, your pumping precision can be dramatically impacted.

graph that depicts dispense volume over 1000 dispenses

This experiment shows repeated dispenses of 50µL with and without a degasser inline. In this experiment, we changed the temperature of the water from 4°C to 20°C. Without a degasser in-line, the dispense accuracy of the pump is varied, showing a higher %CV of reproducibility and a few dispenses that are far below their expected value. This is due to dissolved gasses in the water outgassing with the temperature change. Bubble formation and aggregation can lead to dispensing anomalies in your instrument design. With the test repeated and a degasser placed in line, the reproducibility of the system dispense is greatly improved.

How does a degasser work in an instrument?

Henry’s Law establishes the relationship between gas solubility and temperature. A common example of Henry’s Law is demonstrated when a bottle of soda is opened, the carbon dioxide gas rapidly escapes because the decrease in pressure lowers its solubility in the liquid.

solubility of gas in water chart - temperature versus pressure

For most gases, increasing temperature leads to a decreased solubility in solution. How this impacts instrument design can be demonstrated in the below images:

changes in pressure impact the solubility of gas in solution

as the fluid mixes with samples and other reagents, there is a change in composition - which means a change in gas solubility

once the fluid reaches the detection cell it experiences a change in temperature

Why Partner with IDEX Health & Science for Your Degassing Needs?

We specialize in designing and manufacturing custom degassers tailored to meet the unique requirements of your application. With over 50 years of experience, our team of experts combines cutting-edge technology with unparalleled craftsmanship to deliver solutions that enhance efficiency, reliability, and performance. Our solutions can work with your on-board vacuum pump, or with our proven vacuum solutions.

Key Benefits:

  • Tailored Solutions: We understand that every application is different. Our custom degassers are designed to fit your specific needs, ensuring optimal performance and material compatibility.
  • Innovative Technology: Utilizing the latest advancements in vacuum technology, we provide state-of-the-art solutions that set industry standards.
  • Expert Team: Our highly skilled engineers and technicians bring a wealth of knowledge and experience, guaranteeing top-notch quality.
  • Proven Track Record: Trusted by leading companies across various sectors, our degassers have a proven track record of success and reliability.

Degassing Chamber Specifications

Improve data quality and reliability in your system with degassing chambers from IDEX Health & Science. Find the best degassing chamber for your application by reviewing the data sheets below.

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Related Resources and Products

 

What is the function of a degasser in HPLC?

Degassers are used in High-Performance Liquid Chromatography (HPLC) separations to reduce dissolved air from the mobile phase solvent. The mobile phase state will aid in the proper identification of compounds separated by the HPLC system, along with the stability of the system flow rate. For this reason, nearly all HPLC systems include some form of degassing of the mobile phase and, in some cases, a separate degasser channel is used to improve the accuracy of the autosampler.

Learn more about the critical functions of degassers in HPLC applications.

the critical function of a degasser in hplc

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