Life Science Optics
CMOS and CCD Cameras
For over 20 years, Finger Lakes Instrumentation (FLI), acquired by IDEX Health & Science in 2018, has provided cooled CCD cameras for scientific applications. Life science OEMs have relied on us to provide thousands of cameras with exceptional value and consistent batch-to-batch performance. University and government research labs have looked to us for low volume solutions with optimized specifications. We have supported CCDs from ON Semi (formerly Kodak), Sony, Teledyne e2v, Hamamatsu, and Fairchild. In recent years, we’ve added scientific CMOS cameras, including board level imagers for integration into customers’ sub-systems. We will work with you to select the sensor technology that best fits your needs. IDEX Health & Science can then provide anything from an imaging system to a complete subsystem integrating optics, filters, illumination, and fluidics.
Transitioning from CCD to CMOS?
Watch our recent webinar focused on leveraging all the benefits of CMOS technology and how to make a data-driven decision on selecting your next camera.
BioLineTM CMOS Cameras
The BioLine CMOS platform will offer a range of Sony sensors with various pixel density and formats to meet the diverse needs of Life Science instrumentation.
In low to extremely low light applications, where low levels of dark noise are required, our highly reliable TE-cooling technology is now incorporated in the CMOS cameras. BioLine cameras are designed to acquire higher signal-to-noise (SNR) images and to detect even faint signals at much longer exposures (10 or more minutes).
For multiplex imaging in spatial OMICS applications, high sensitivity and resolution with a high dynamic range are vital. Our larger format CMOS cameras will offer an extensive diagonal field of view to increase throughput and amount of data captured while maintaining high sensitivity and high QE. Other CMOS sensors available per your request. Book your demo unit and request preliminary specifications of our larger format CMOS cameras, IMX571, IMX492, and IMX455.
Kepler CMOS Cameras
Kepler cameras add CMOS sensors and high speed to our product portfolio. The back-illuminated KL400 has a peak quantum efficiency of 95% and delivers 24 high dynamic range frames per second with 1.5 electrons noise. In 12-bit mode, an 80 x 2000 subarray can exceed 1000 frames / second. The larger area of the KL4040 (37 x 37 mm) is alternative to complex step-scanning solution. We will continue to add new CMOS sensors to address customers’ needs. Kepler KL cameras include USB 3.0 interfaces as well as a QSFP (quad small form factor pluggable) cages for high-speed fiber optic communication. Air cooling and plumbing for liquid circulation are standard. Electromechanical shutters are optional to ease acquisition of calibration dark images.
In 2021, KL2020 joined the Kepler family and provided a game-changing solution for life science applications. This OEM camera offers high QE, high frame rates, and exceptional SNR ratio at a very competitive price.
MicroLine CCD Cameras
MicroLine and Hyperion cameras have long set the standards for price / performance for scientific CCD imaging. MicroLine cameras are small and lightweight, yet deliver extraordinary performance in cooling, noise, frame quality, and digitization bit-depth. With exceptionally low dark current and high sensitivity it makes it ideal for low light fluorescence applications.
Hyperion was developed for OEMS with a need for shorter distance front-to-back. MicroLines and Hyperions share electronics in differently shaped housings to satisfy customers’ mechanical requirements.
Sensors in all cameras are deep cooled in long-life maintenance-free sealed chambers. Regulated cooling stabilizes results for improved calibration. Cooling also minimizes thermally generated dark signal and maximizes dynamic range.
Camera Capabilities
| BL183* | BL428* | KL400 | KL4040 | KL2020* | MLx285 | MLx695 | |
| Sensor Technology | CMOS | CMOS | CMOS | CMOS | CMOS | CCD | CCD |
| Sensor Architecture | Back Illuminated | Back Illuminated | Back Illuminated / Front Illuminated | Back Illuminated / Front Illuminated | Back Illuminated / Front Illuminated | Front Illuminated | Front Illuminated |
| Peak QE (%) | 84 | 77 | 95 (BI) / 58 (FI) | 90 (BI) / 74 (FI) | 94 (BI) / 72 (FI) | 62 | 75 |
| Pixel Size (µm) | 2.4 | 4.5 | 11 | 9 | 6.5 | 6.45 | 4.54 |
| Array Size | 20 MP (5472 K x 3648 K) | 7 MP (3208 K x 2200 K) | 4 MP (2 K x 2 K) | 16 MP (4 K x 4 K) | 4 MP (2 K x 2 K) | 1.3 MP (1360 K x 1024 K) | 6 MP (2750 K x 2200 K) |
| Sensor Area (mm) | 13.1 x 8.7 | 14.4 x 9.9 | 22.5 x 22.5 | 36.9 x 36.9 | 13.3 x 13.3 | 8.8 x 6.6 | 12.5 x 10.10 |
| Diagonal (mm) | 15.7 | 17.4 | 31.9 | 52.1 | 18.8 | 11 | 16 |
| Full Well (e-) | 16 | 16 | 92 (BI) / 120 (FI) | 39 (BI) / 70 (FI) | 55 (BI) / 45 (FI) | 18 | 17 |
| Data Bit-Depth (bit) | 12 | 12 | 16 | 16 | 12/16 | 16 | 16 |
| Spectrum Capability (nm) | 300 – 1000 | 300 – 1000 | 200 - 1100 (BI) 300-1000 (FI) | 200 - 1100 (BI) 300-1000 (FI) | 200 - 1100 (BI) 300-1000 (FI) | 300 – 1000 | 300 – 1000 |
| Dark Current (typical) | 0.003 eps @ -15 C | 0.003 eps @ -15 C | 0.4 eps @ -20 C (BI) / 0.2 eps @ -20 C (FI) | 1 eps @ -10 C (BI) / 0.15 eps @ -20 C (FI) | 0.2 eps @ -20 C (BI & FI) | 0.001 eps @ -25 C | 0.0007 eps @ -30 C |
| Read Noise (e-; typical) | 2.7 (rolling) | 3.9 (HG) | 1.6 (BI) / 1.5 (FI) | 2.1 (BI) / 3.7 (FI) | 1.2 (HG)(BI) / (FI) | 4.5 | 3 |
| Shutter Type | Rolling | Global | Rolling | Rolling | Rolling | Global | Global |
| Frame Rate | 20 fps | 26 fps | 24 / 48 | 23(QSFP) | 28 (HDR), 41 (2-CMS), 43 (QSFP) | 4 | 1.4 |
| Cooling | delta 40 C | delta 40 C | delta 45 C | delta 40 C | delta 40 C | delta 60 C | delta 60 C |
| Interface | USB 3.0 | USB 3.0 | USB3 / QSFP | USB3 / QSFP | USB3 / QSFP | USB2 | USB2 |
| Binning | Yes | Yes | No | No | No | Yes | Yes |
*Preliminary
