Stories & Features

When analytical scientists review their HPLC laboratory set-ups, they typically have a couple goals in mind. How can we enhance the performance of the system and produce repeatable, certifiable results? What methods could we implement to increase the efficiency of the system? To work through these goals, an often overlooked but key element to consider is the degasser.
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Businesses in the analytical laboratory market are constantly looking for modern management and productivity processes to adopt. Methods are increasingly developed using QbD (Quality by Design) principles and are subject to active life cycle management. The main goals of innovating and adopting new technologies include repeatable and certifiable performance, maximum efficiency and cost-effective operation, along with improved environmental awareness.
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Utilize degassing in your fluidic path to remove dissolved gases from fluids before they outgas and form problem-causing bubbles.
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Life Science instrument designers face many challenges when incorporating a fluid delivery system into an instrument. Many instruments on the market use a single positive displacement dispense pump because they are compact and easy to integrate. These systems force designers to make multiple compromises because pump displacement volume, pressure handling, flow rate, and flow duration are all interrelated. How can you achieve accurate, stable flow rates with unlimited flow in your liquid chromatography and mass spectrometry instruments?
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Every time a traditional UHPLC valve is rotated to make an injection in a UHPLC system, the pressure of the mobile phase flowing through the column fluctuates. When switching from load to inject, the system experiences a 11,000 psi (758 bar, 76 MPa) pressure drop. In addition to the injection pressure drop, the column also experiences a pressure drop when the valve switches back to the load position from the inject position. Over time when switching the valve repeatedly, these pressure drops can disrupt column packing and cause the column to experience an early lifetime failure.
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During reagent handling or at the connection junctions, even small changes in the fluid path can cause dissolved gasses to occur in a solution. Factors including pressure, temperature, and chemical mixing are sources of bubble formation. Bubbles in the fluid stream cause detection variables, which can produce unstable, wandering, or noisy baselines. How do you prevent these variable changes in your fluid path? A Degasser
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Fluidic applications with multiplexed reagents tend to result in complicated system designs and manufacturing. If each flow path is not carefully developed, your system will be vulnerable to leaking or kinks, and can trigger a myriad of obstacles such as increased system-volume, excess heat generation, and inaccurate results.
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How do you handle customized fluidic design iterations when you are on a tight timeline and budget? In fluidic pathway development, the most efficient way to optimize your system is to integrate a manifold to reduce device size, decrease leaks, and add valves and pumps. This will improve reliability of the flow path and provide consistent performance.
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