When analytical scientists review their HPLC laboratory set-ups, they typically have a couple goals in mind.
To work through these goals, an often overlooked but key element to consider is the degasser.
To maintain the stability of the HPLC system flow rate and mobile phase composition, a degasser plays the sole role in reducing the amount of dissolved air in the mobile phase and the stability of the entire HPLC system. Today’s HPLC systems have 2 potential mobile phase mixing arrangements. In the first scenario, solvents are mixed before they enter the pump. In the second scenario, mobile phase mixing occurs after the pump but before the injection valve. Both scenarios will help avoid chromatographic errors if the HPLC system incorporates an efficient, in-line vacuum degasser for the mobile phase mixture and its components.
Analytical instrument manufacturers should consider:
Our new technology represents a transition from ‘constant vacuum’ to ‘constant performance’, by allowing users to select and control a fixed degassing efficiency for any HPLC system. Learn more about this next-generation degassing technology in this Labmate article by our Principal Scientist, Carl Sims.
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