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To explore how learning and memory-building take place in the brain, scientists at Johns Hopkins University School of Medicine used a laser-assisted imaging tool to monitor and measure levels of AMPAR molecules, which help send messages between neurons, in mouse brains. Their experiments, they said, add to evidence that motor-based learning can occur in multiple areas of the brain, even in areas not typically associated with motor control.
The scientists injected DNA-encoding AMPARs carrying a fluorescent tag into the brains of mice and used an electrical pulse to force the neurons to absorb the AMPAR DNA. Using in vivo two-photon microscopy, they measured the amount of fluorescence coming from the tagged AMPARs. Higher amounts of…READ MORE