The LCGC Blog: Water immiscible solvents as sample diluents in reversed-phase HPLC – you must be joking! - IDEX Health & ScienceIDEX Health & Science

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    The LCGC Blog: Water immiscible solvents as sample diluents in reversed-phase HPLC – you must be joking!

    Article obtained from LCGC Liquid Chromatography (LC/HPLC) RSS Feed.

    Many of us have faced the situation where we have analytes that vary widely in their polarity or LogP(D) values and encounter issues with analyte solubility when choosing a suitable sample diluent for our high-pressure liquid chromatography (HPLC) analysis. The more polar analyte will favor aqueous solvents, and the less polar will be more highly soluble in organic solvent—so which do we choose?

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    Mar, 09 2021 |

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