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Scientists led by MIT’s Edward Boyden have applied the principles of expansion microscopy — a technique that Boyden’s lab introduced in 2015 — to develop an inexpensive imaging method that uses an ordinary light microscope to image at the scale of individual virus particles. Key to the method is a new type of hydrogel that maintains a more uniform configuration than that typically used in conventional expansion microscopy. In that technique, scientists embed biological samples in a hydrogel and expand them before imaging them with a microscope.
In addition to individual virus particles, researchers said the advancement could allow them to eventually image single biomolecules. Imaging with that degree of…READ MORE