Superresolution Microscopy Images Key Alzheimer’s Protein - IDEX Health & ScienceIDEX Health & Science


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    Superresolution Microscopy Images Key Alzheimer’s Protein

    Article obtained from Photonics RSS Feed.

    As superresolution microscopy has advanced, so too has scientists’ ability to dive deep into the neural network and the compounds that accumulate in conjunction with a variety of conditions. And a team at the VIB-KU Leuven Center for Brain & Disease Research has seized on this technology to understand a protein complex that is common in patients with Alzheimer’s disease and with cancer.

    The γ-secretase complex is an enzyme composed of catalytic presenilin (PSEN), nicastrin (NCT), anterior-pharynx defective 1 (APH1), and presenilin enhancer 2 (PEN2) in a 1:1:1:1 ratio. The compound breaks down when this ratio is not present.
    PSEN1/γ-secretase diffusion is fast at the cell surface. This is a…

    Jul, 21 2020 |

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