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    Spectroscopic Toolkit for Structural Biology Could Aid in Drug Design

    Article obtained from Photonics RSS Feed.

    A fluorescence-based imaging technique for monitoring single molecules could lead to a better understanding of how molecules are assembled, function, and interact, aiding in structure-guided drug design.

    Clemson University researchers led by professor Hugo Sanabria and working with researchers from Heinrich Heine University developed a hybrid fluorescence spectroscopic toolkit to study the essential reaction steps of enzymes. By combining single-molecule and ensemble multiparameter fluorescence detection, electron paramagnetic resonance spectroscopy, and Förster resonance energy transfer (FRET)-positioning and screening, as well as other biochemical and biophysical tools, they characterized three short-lived conformational…

    Mar, 10 2020 |

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