SEC-MALS as a Platform and Release Assay for AAV Development and Production - IDEX Health & ScienceIDEX Health & Science

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    SEC-MALS as a Platform and Release Assay for AAV Development and Production

    Article obtained from LCGC Liquid Chromatography (LC/HPLC) RSS Feed.

    As one of the most promising in-vivo gene delivery vectors, adeno-associated virus (AAV) has been widely used in various gene therapy products. In order to ensure the safety and efficacy of these AAV-based gene therapy products, it is crucial to understand and measure their critical quality attributes (CQAs) throughout the development cycle. In this podcast, we will discuss how to apply a well-established bio-therapeutics characterization tool, SEC-MALS (size-exclusion chromatography combined with multi-angle light scattering and other online concentration detectors), for quantifying AAV CQAs. This SEC-MALS method has been recognized and demonstrated as a robust, sensitive, and automated assay for AAV development platform and production release testing.

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    Apr, 07 2021 |

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