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Researchers at Ghent University have detected protease using surface-enhanced Raman spectroscopy (SERS) performed with a tiny waveguide. The work moves toward real-time, label-free, lab-on-a-chip protease monitoring, which could offer a high-throughput approach to screen for new drugs that inhibit proteases involved in disease. Proteases, which break down the peptide bonds that hold proteins together, play an important role as drug targets due to their functionality in diseases such as cancer, Alzheimer’s disease, and arthritis.
“We hope that our interdisciplinary approach can one day enable fast and efficient discovery of new drugs for a variety of protease-linked diseases, thus improving lives of millions of patients around…