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Tufts University researchers have shown that glucose levels can be controlled in a mouse model of diabetes through optogenetics. When exposed to light, engineered pancreatic beta cells transplanted into diabetic mice produced more than two to three times the typical level of insulin.
The light-switchable cells are designed to compensate for the lower insulin production or reduced insulin response found in diabetic individuals. The researchers sought to develop a new way to amplify insulin production while maintaining the important real-time link between the release of insulin and concentration of glucose in the bloodstream. Using optogenetics, they engineered pancreatic beta cells with a gene that encodes a photoactivatable adenylate…READ MORE