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A team of scientists in Spain has directly photomodulated brain-state transitions in vivo using a photoswitchable molecule that was developed previously by researchers at the Institute for Bioengineering of Catalonia (IBEC). By applying a light-responsive molecule called phthalimide-azo-iper (PAI) to the intact brain and subsequently to white light, the researchers were able to modulate slow oscillations in neuronal circuits and reversibly manipulate the oscillatory frequency of the brain.
The chemically engineered mechanism allowed the researchers to induce and investigate brain transitions from sleep-like to awake-like states in detail, and in a noninvasive way.
The method for using light to enable PAI to modulate brain…READ MORE