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Researchers at Bielefeld University have demonstrated improvements in superresolution structured illumination microscopy (SR-SIM), demonstrating that the technique is possible in real time and at a very high imaging rate, which is enhancing observation of even the smallest cell particles.
“Unlike other conventional fluorescence microscopy methods, SR-SIM does not illuminate the specimens uniformly, but with a fine, grid-like pattern. This special technology enables much higher resolution,” said Thomas Huser, a physics professor and head of the Biomolecular Physics Working Group at Bielefeld. “The problem so far has been that microscopes offering a sufficiently high resolution cannot display information at the…READ MORE