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A team at Nagoya University’s Institute of Transformative Bio-Molecules has developed a marker molecule that bypasses the problem of photobleaching in STED microscopy. It’s allowing an unprecedented view of live mitochondria, which could help researchers better understand, diagnose, and potentially cure human mitochondrial disease.
The new marker molecule — MitoPB Yellow — is absorbed by the inner membrane of mitochondria, which includes the cristae (fold-like structures), and has demonstrated a long lifetime under a STED beam.
According to the researchers, existing marker molecules succumb to photobleaching when they degrade under intense STED beams and stop fluorescing, making it nearly impossible to…READ MORE