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Using multiphoton microscopy (MPM), researchers at Kyoto University showed that the collagen fibers in the skin are arranged in a mesh-like lattice and not in a clear geometric orientation as previously thought. They further found that the connective tissue in the skin, known as elastic fibers, is arranged in the same way as the collagen.
The study by the Kyoto team aimed to characterize the geometric organization of collagen fibers in the entire dermis layer ex vivo by using a new microscopic technique that combines MPM (the tissue clearing method) and biaxial extension. The researchers hypothesized that tissue clearing would allow observation of deep dermal layers, and biaxial extension would facilitate identification of individual…READ MORE