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Article obtained from BioPhotonics RSS Feed.
Researchers from Washington University in St. Louis have found a mechanism to efficiently and accurately measure the point spread functions (PSFs) of the position of molecules, called variance upper bound (VUB). They believe this will someday aid scientists and clinicians as they look to understand what is happening at the molecular level in the body.
The researchers specifically used fluorescent molecules to bind with amyloid fibers and measure their differences in structure. As it turns out, in so doing, they found a way to bypass typical limitations associated with single-molecule localization microscopy (SMLM) and single-molecule orientation localization microscopy (SMOLM) in the laboratory, which have difficulty tracking…READ MORE