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    Marriage of Microscopy Techniques Reveals Cells’ 3D Ultrastructure

    Article obtained from Photonics RSS Feed.

    Scientists at the Howard Hughes Medical Institute (HHMI) have combined superresolution fluorescence microscopy and electron microscopy to shed new light on the structures and organizations within cells.

    Superresolution fluorescence microscopy on its own is able to show cellular structures with a high degree of clarity and detail, though the technique does have its limits. Only a few of the more than 10,000 proteins in a cell can be revealed, which does not provide researchers with enough information to study the interconnections and dependencies of cellular structures.

    Electron microscopy, on the other hand, comes with its own set of pros and cons. The technique is able to reveal all cellular structures in high resolution, but…

    Jan, 20 2020 |

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