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With the help of a custom-built lattice light-sheet microscope, researchers at the Walter and Eliza Hall Institute (WEHI) captured high-resolution 3D video images of individual malaria parasites (Plasmodium falciparum) invading red blood cells in real time, and they observed the molecular and cellular changes that occurred throughout the very fast process.
Their use of lattice light-sheet microscopy (LLSM) provided views capable of providing new insight into malaria parasite biology that could have applications for the development of antimalarial medicines.
“In the past, the choice of microscope for an experiment had to be a compromise between capturing a lower-resolution video, which revealed dynamic processes like shape…READ MORE