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An optical mapping system has demonstrated that hydroxychloroquine (HCQ) can cause arrhythmia in animals, so researchers and clinicians are cautious about its effectiveness as a treatment of COVID-19 in people. Previously, HCQ, a less toxic form of chloroquine (CQ), has been prescribed to those with malaria and various autoimmune conditions and has showed some promise in reducing COVID-19 symptoms in a limited number of cases.
Images show the voltage surface on a rabbit heart with and without HCQ. Without the drug (normal), the electrical activation spreads homogeneously, while with HCQ, waves propagate unevenly, generating complex spatiotemporal patters and arrhythmias. Courtesy of Georgia Tech School of Physics.
But with the aid of…