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Researchers at the Salk Institute have developed a new imaging method that allows them to monitor actin, a small subset of skeleton-like filaments within cells. The method has enabled research on how actin mediates an important function: helping mitochondria divide in two. The research could allow for a better understanding of mitochondrial dysfunction, which has been linked to cancer, aging, and neurodegenerative diseases.
“Actin is the most abundant protein in the cell, so when you image it, it’s all over the cell,” said Uri Manor, director of Salk’s Biophotonics Core facility and corresponding author of the paper. “Until now, it’s been really hard to tell where individual actin molecules of…READ MORE