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Even though scientists have engineered bacteria to make therapeutic proteins, medicines based on these proteins, such as insulin and clotting factors for hemophilia, are still difficult to synthesize in the lab. Now, through the use of green fluorescent protein, researchers at Washington University School of Medicine have found a way to supercharge protein production a thousandfold. The discovery resulted from an experiment that turned out differently than expected.
While investigating how to control the amount of protein produced from a specific gene, professor Sergej Djuranovic and researcher Manasvi Verma experimented with changing the sequence of the first few amino acids of a protein. “We thought it would have no effect on…READ MORE