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Researchers at the New York Genome Center and New York University have developed a new kind of CRISPR screen technology to target RNA. Many CRISPR-based genetic screens can only edit or target DNA, and cannot target RNA viruses like coronavirus or flu.
Using a recently characterized CRISPR enzyme called Cas13 that targets RNA instead of DNA, the researchers engineered a platform for massively parallel genetic screens targeting messenger RNAs of a green fluorescent protein transgene and other cell-surface proteins in human cells. By targeting thousands of different sites in human RNA transcripts, the researchers developed a machine learning-based predictive model to expedite identification of the most effective Cas13 guide RNAs. Using…READ MORE