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    Cable-Free Brain Imaging Technique Proves Less Invasive, Shows Promise In Neuroscience

    Article obtained from Photonics RSS Feed.

    Researchers at Osaka University have developed a method to record brain activity in multiple freely moving mice simultaneously. The method is based on a recent bioluminescence-based indicator of membrane voltage.

    Researchers applied the indicator (called LOTUS-V) to cells in the primary visual cortex, which is known to respond to locomotor activity and visual stimulations. The bioluminescent probe is genetically encoded — delivered to target cells noninvasively via a common gene expression system (the adeno-associated virus). Its signal is derived from cell membrane voltage changes, which reflect brain activity in response to visual stimuli and locomotor activity, including interactions with other mice.


    Jun, 06 2019 |

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