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Researchers at Osaka University have developed a method to record brain activity in multiple freely moving mice simultaneously. The method is based on a recent bioluminescence-based indicator of membrane voltage.
Researchers applied the indicator (called LOTUS-V) to cells in the primary visual cortex, which is known to respond to locomotor activity and visual stimulations. The bioluminescent probe is genetically encoded — delivered to target cells noninvasively via a common gene expression system (the adeno-associated virus). Its signal is derived from cell membrane voltage changes, which reflect brain activity in response to visual stimuli and locomotor activity, including interactions with other mice.