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Two-Photon Imaging and Neuropsychiatric Disease
Since its introduction to neuroscience, two-photon imaging has been used to image synaptic connections in living animals. The formation of synapses, their solidification, and disappearance forms one fundamental aspect of how intact brain circuits learn, memorize, and forget. Synaptic-scale two-photon imaging has also brought to light key mechanisms underlying neuropsychiatric diseases such as epilepsy, multiple sclerosis, or schizophrenia. Recent synaptic imaging in mice during prolonged anesthesia highlights once again, how two-photon microscopy may help to connect the dots and drive paradigm shifts in patient care, in this case, intensive care medicine. It’s long known that…
