Innovations in the STORM Method Reveal Vital Clues to Disease Formation
https://www.photonics.com/Articles/Innovations_in_the_STORM_Method_Reveal_Vital/a68448
Scientists and clinicians have long believed that visualizing structural changes in the nucleus of cancer cells would unlock vital clues about how the disease first forms. This information could provide the ability to track where and how cancer is progressing to plan its successful treatment. Traditional microscopy methods have fallen short in revealing these details because the microscope’s inherent resolution limit only allows the imaging of general structural changes, as opposed to resolving their point of origin. Finding fluorescent dyes that illuminate abnormalities, such as aggregated proteins, at the single-molecule level and effectively target their spatial distribution has also not been easy. Innovations in superresolution...
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