Developing Novel Fluidic Solutions for Analytical Challenges Associated with LC-MS Capillary Column Separations

IDEX Health & Science, a global leader in fluidics technology, is developing capillary column capability for LC-MS centered around a novel tube-in-manifold design. It is comprised of a replaceable, bioinert, high-pressure capillary column module with an integrated rotary shear valve. The design addresses the robustness issues associated with delivering optimally separated components, at ultra-low flow rates, to nanoliter flow cells and electrospray MS emitters.

Some of the capabilities being evaluated at IDEX Health & Science as part of this initiative include:

• Comprehensive use of Computational Fluid Dynamic (CFD) Modelling
• Minimization of System Dead Volume
• Bioinert Fluid Path
• Accurate Control of Temperature
• Interfacing Post Column Modules
• Robust Packing Tools and Techniques

Author:

Graham Shelver Ph.D., Lead Application Scientist, IDEX Health & Science, Research & Development