Microfluidics & Consumables

Comprehensive Microfluidics Solutions for Diagnostics and Life Science Research

As the world of life science becomes increasingly complex, developers are challenged to build solutions that enable more analysis on smaller samples with easier user workflows. Whether you’re creating instruments for life science research or diagnostics, there’s a likelihood your application will require microfluidics. Our experts enable microfluidics that simplify complex assays for a wide range of applications, and we partner with you to develop intricate technology while streamlining functionality, manufacturability, and costs.

Learn more about our microfluidic applications by hovering over the path and reading below.

 

fluidics

 


Next Generation Sequencing (NGS)

Transforming the Understanding of Molecular Biology at the Genomic Scale

Since the completion of the human genome project in 2003, the cost of sequencing has significantly decreased, making it accessible to a large community of researchers. This has allowed Next-Generation sequencing to revolutionize the way genetic and molecular biology studies are conducted.

With its unique capabilities for handling small volumes of samples and multiplexing, Microfluidics is highly complementary to NGS technology enabling digital PCR, multiple displacement amplification, quasilinear amplification, or targeted sequencing.

IDEX Health & Science plays a significant role in the development of massive parallel sequencing platforms. From Sanger Sequencing to Sequencing-by-Synthesis to Single-Molecule-Sequencing – in close collaboration with our customers we develop imaging flow cells including the related linker and capture chemistries and microfluidic consumables like droplet generators.

Our experts are excited to team up with scientists and instrument developers to develop the next platforms for Next-Generation Sequencing technologies. We are also a leading supplier of glass and crystalline components to vertically integrated OEMs who prefer to use their own flow cell technology. Cleanliness plays a key role in flow cell manufacturing. Whether leveraging our state of the art cleaning facilities or our cleanrooms, we are capable of offering products with the surface qualities you require.

We draw upon a considerable range of technologies and capabilities to manufacture a full spectrum of flow cells, from large scale devices to microfluidics. Our years of flow cell experience results in innovative design guidance and cost effective manufacturing processes. Whether your application involves components for OEM instruments, production tooling, or consumables, we have the technology, know-how, and experience to design, prototype, and mass-produce flow cells and other microfluidic consumable such as droplet generators or sample splitters for your applications.

 


Droplet-Based Applications

Reliable Precision for the Effective Use of Limited Materials

The precise generation and manipulation of micro droplets is key in applications like nucleic acid detection, imaging, drug delivery, and diagnostics. Droplet-based microfluidics enables very high throughput while working with small sample sizes, such as primary cells, patient’s biopsies, or expensive reagents. The formation of precise droplets enhances sensitivity and eliminates spurious background noise by discretizing the sample in droplet-sized entities.

The development of consumable microscale droplet generators requires high precision micro-channels at the lowest tolerances possible. IDEX Health & Science is an expert in designing and manufacturing of channels and droplet chambers to almost any needed channel size features. We are proud to state that IDEX Health & Science is capable in mass producing droplet microfluidics at channel tolerances of +/- 1µm. Over the past years together with our customers we developed droplet fluidic applications in cell culture incubation, protein crystallization, chemical synthesis PCR, and DNA Sequencing to name just a few.

 


Diagnostics and Point-of-Care

Bringing Patient and Diagnosis Closer Together

With Point-of-Care (POC) we see a shift away from diagnostic testing in a clinical laboratory setup to a near-patient environment providing timely diagnostic information to make quick informed decisions on diagnosis and treatment. Changes in the healthcare industry promote the development of inexpensive and easy-to-use diagnostic devices that provide timely health status information at the point of care.

Microfluidics is an enabling technology for point-of-care diagnostic devices. The manipulation of small volumes of liquids plus the ability to perform all assay steps, including sample preparation, reaction, separation, and detection, together on one device, creates an all-in-one Sample-to-Answer solution. The combination of fluid technologies, both on the micro- and macro-scale, allows parallel processing of samples, ensuring fast sampling, together with the accurate and precise control of multiple samples and reagents simultaneously.

We have the broadest solutions for microfluidics technologies available, and proven experience in the collaborative development of point-of-care consumable devices. IDEX Health and Science is one the few OEM suppliers with a demonstrated capability to make complex assays work on microfluidic cartridges. We partner with our customers to create functional Sample-to-Answer solutions with integrated sample transfer, dry and wet chemistry storage, pumps, valves, sensors, and optical interfaces.

All our projects start with manufacturability and cost-efficiency in mind. Our ability to manufacture and combine plastic, glass, reagent, and detection components is unrivaled by others in the life science industry. As an ISO13485 certified production company with over 20,000 sqf. of clean-room facilities and automated assemblies, we are your partner not just in design and development but also in manufacturing devices to the highest industry standards and healthcare regulations. Our facilities also have the capability of shipping devices directly to your customers from our manufacturing floors, complete with your branded packaging.

 

 


Multiplexed Molecular Assays

Reduce Workflow and Sample Volume Limitations

Multiplexed assays, including nucleic acid detection and immunoassays, combine assays for many target analytes in a single reaction volume, reducing workflow and sample volume limitations. When detecting similar analytes, cross reactions can have a negative impact on the results. Current microfluidic solutions to this problem involve spatial separation of critical reactions by bead-based flow cytometry, microwells, and micro reaction chambers. Additionally, microfluidic platforms implement precise aliquoting functions leading to improved accuracy and precision, reduced consumption of sample and reagents, and the ability to automate research tasks on one card or chip. The throughput of such lab-on-a-chip devices can be increased additionally by parallelization of assay procedures on one card.

IDEX Health & Science is one of the few OEM suppliers with a demonstrated capability to make complex assays work on microfluidic cartridges. We master all microfluidic tasks from sample preparation and sample splitting to distribution, reagent storage and handling, valve and pump functionalities, and sensor integration. Together with our customers we developed multiplexed and/or parallelized solutions for next gen sequencing, metabolic panels, cardiac markers, circulating tumor cells, veterinary diseases and respiratory infections to name just a few. Our capabilities to manufacture and combine plastic, glass, reagent, and detection components is unrivaled by others in the life science community. As an ISO13485 certified company with over 20,000 sqf of clean-room facilities and automated assemblies, we are your partner not just in design and development of your multiplexed solutions, but also in manufacturing devices to the highest industry standards and healthcare regulations.

 


Target Enrichment Workflows

Avoid the Need for Sequencing Large Numbers of Complex Genomes

Target enrichment workflows have been developed to focus on specific genomic regions to avoid the need of sequencing large numbers of complex genomes in their entirety. Genomic regions are selectively captured from a DNA sample before sequencing. Re-sequencing the retained regions is more cost-effective, speeds up the whole process, and reduces the complexity of the resulting data to analyze.

From the generation of microdroplets for PCR-based enrichment, to molecular inversion probes on microfluidic chips, to hybrid capture methods with modified beads, Microfluidics plays a key role in target enrichment workflows.

Our company is a leading supplier for microfluidic consumables for target enrichment workflows. In close collaboration with our partners we develop microfluidic chips with related chemical immobilization, such as linker chemistries or purification molecules, chips for optical analyte detection, or microfluidic consumables like droplet generators to enable Digital PCR platforms.

We are also a leading supplier of glass and crystalline components for vertically integrated OEMs who prefer to use their own flow cell technology. Cleanliness plays a critical role in flow cell manufacturing. Whether leveraging our state-of-the-art cleaning facilities or our cleanrooms, we are capable of offering products with the surface qualities you require.
 

Liquid Biopsy


The Perfect Tool for Diagnosing and Monitoring Diseases from Various Bodily Fluid

The majority of present applications use blood for the identification of cellular and molecular signatures to detect early-stage cancer, predict disease progression, and monitor response to chemotherapeutic drugs and overall treatment efficiency.

Most of liquid biopsies applications are targeting circulating tumor cells, circulating tumor DNA and circulating RNA. Conventional cytological examination of body fluids suffer from serious drawbacks such as low sensitivity, loss of targeted cells through mechanical stress, and large sample volumes. Microfluidic platforms offer many advantages over classic benchtop applications. Microfluidic solutions for liquid biopsies require only low volumes of sample and reagent, offer high sensitivity, and a controllable flow pattern.

IDEX Health and Science developed several solutions to efficiently detect and isolate cancer cells. We are proud to state that our facilities are capable of mass producing microfluidic chips for liquid biopsy in unmatched accuracy and precision in micrometer range along with the surface chemistry needed.

Read more about Engineered Nanointerfaces for Microfluidic Isolation and Molecular Profiling of Tumor-Specific Extracellular Vesicles
 

Organ-On-A-Chip Devices

Enhance Research with Devices that Simulate Entire Organs and Organ Systems

Organ-on-a-Chip Devices are simulations of entire organs or organ systems on a microfluidic cell culture chip. The use of organ-on-chip devices in pharma research is meant to enhance the transfer of pre-clinical results into the clinical phase. This expedites development and saves costs. Another advantage is the reduced need for animal testing and the possibility to study side effects on different organs when the chip is laid out to represent a whole organ system.
 
Deriving from lab-on-a-chip technology, organ-on-chip devices are the meeting point of microfluidics and human cell biology. Cells and tissues need to be cultured in a 3-dimensional microfluidic structure enhancing growth rate and forming patterns simulating the targeted organ systems. When designing an organ-on-a-chip device the surface effects need to be thoroughly considered together with the fact that mixing in microfluidic dimensions is challenging when trying to mimic real-life environments.
 
We have the expertise and technology to collaborate with customers to develop sophisticated organ-on-a-chip devices and take care of all microfluidic considerations needed. Our capabilities to manufacture and combine plastic, glass, reagent, and detection components is unrivaled by others in the life science community. We are proud to state that we are capable of mass producing microfluidic organ-on-a-chip devices in unmatched accuracy and precision in micrometer range along with the required surface structures.  

 

Cell Isolation

Efficiently Isolate and Sort Cells for Diagnosis and Research

Normal and diseased cells differ in gene expression, protein secretion, and other crucial information. Efficient isolation and sorting of cells are critical preparatory steps for disease diagnosis and other biological research. Based on their inherent differences in cellular morphology, cells can be sorted by specific microfabricated structures, traps, or filters. Microfluidic devices effectively isolate target cells from a large population of cells, either by physical traps or biological recognition.

Microfluidic technologies enable marker-free cell separation in a number of ways. The design of microstructures and dimensions determine the separation efficiency in cell isolation. Microfluidic centrifugation isolates cells by size difference. Acoustic wave-based cell isolation and isolation by dielectrophoresis are yet two other technologies applied in microfluidic structures. Microfluidic devices can further be combined with droplet generators that encapsulate captured cells or with molecular assays of captured cells for clinical cancer diagnosis.

IDEX Health & Science has the expertise and technology to collaborate with its customers in order to develop sophisticated solutions for cell isolation, sorting, and all other microfluidic consideration needs. Our capabilities to manufacture and combine plastic, glass, reagent, and detection components is unrivaled by others in the life science community. We are proud to say that IDEX Health & Science is capable of mass producing microfluidic solutions for cell isolation and is unmatched in accuracy and precision within the micrometer range and required surface structures. As an ISO13485 certified production company with over 20,000 square feet of clean-room facilities and automated assemblies, we are your partner, not just in design and development of your targeted solution, but also in manufacturing devices to the highest industry standards and healthcare regulations.
 

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Contact one of our Custom Order groups to start the conversation about custom microfluidics.


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IDEX Health & Science is the global authority in fluidics and optics, bringing to life advanced optofluidic technologies with our products, people, and engineering expertise. Intelligent solutions for life.