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To expand the toolbox of imaging in living cells, researchers from Colorado State University and the Tokyo Institute of Technology have developed a genetically encoded, antibody-based probe that works with specificity in vivo. Probes built from antibodies were genetically fused with mature fluorophores. When loaded into cells, the probes bind and light up specific targets (epitopes) within the proteins of interest as soon as the epitopes are accessible. The probe, called the human influenza hemagglutinin (HA) frankenbody, can light up, in multiple colors, HA-tagged nuclear, cytoplasmic, membrane, and mitochondrial proteins in diverse cell types.
Like stitching new limbs on a body — hence the name “frankenbody”…READ MORE