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Wound healing, memory formation, disease detection — these complex biological interactions have remained an enigma to researchers. The primary issue comes with the most common method for imaging deep into live tissue: It’s hampered by optical spherical imaging, which limits the ability to view delicate structures such as dendritic spines. In this issue’s cover story, Carlo Alonzo of the Scientific Solutions Group at Olympus Corp. of the Americas discusses how microscope objectives equipped with adjustable correction collars can compensate for the aberration — yielding submicron resolution that enables researchers to glean insights into dynamic events with little disruption to the biological system.
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