Isolation Technologies: Glossary of Terms

This Glossary of terms has been compiled for your convenience. To view the terms and their descriptions, click a letter from the list below.

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M

Microbore
Term typically applying to columns used in HPLC applications where the inner diameter is less than or equal to 2 mm. It also is used describing a family of HPLC applications in which this size of column is used.

Modular
This is the term used for the Isolation Technologies threaded column hardware. Modular HPLC hardware is designed to be even more user-friendly than ordinary compression style hardware. With modular hardware, there is no need to apply precise torque to get the ferrule to grip the tube. The high pressure seal is instead formed by the threads on the tube and end fitting. There is also no problem of the frit not seating in the end fitting. The frit is contained in a cap that slides over the column forming a leak and gap-free seal. ITs modular hardware also eliminates safety concerns when packing at high pressures.

Modular Bio-Safe
Bio-Safe is a Isolation Technologies trade name. This is also called a peek modular system. IT’s Bio-Safe™ modular columns are biocompatible and precision machined from virgin PEEK (polyetheretherketone), a strong, inert polymer material.

Why PEEK?
PEEK columns are used when analytes are sensitive to the metals in conventional stainless steel hardware. Proteins, peptides and ions have this susceptibility. Interaction of sensitive biomolecules with metal can lead to loss of biological activity, loss of sample from adsorption, low efficiency and poor peak shape. PEEK is also compatible with most mobile phases used in reversed phase HPLC, with the exception of THF. Bio-Safe PEEK tubing also has superior wall thickness for strength, and an ultra-smooth internal surface finish for high efficiency.

Like the modular stainless steel line, Bio-Safe columns are threaded and provide a safe column format for high pressure packing up to 8000 psi. IT also offers a packing adapter for the Bio-Safe line.

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